2014/2015 Publications

 

ANTEL JACK

Preisner A, Albrecht S, Cui QL, Hucke S, Ghelman J, Hartmann C, Taketo MM, Antel J, Klotz L, Kuhlmann T. Non-steroidal anti-inflammatory drug indometacin enhances endogenous remyelination. Acta Neuropathol. 2015 Aug;130(2):247-61. doi: 10.1007/s00401-015-1426-z.

Podjaski C, Alvarez JI, Bourbonniere L, Larouche S, Terouz S, Bin JM, Lécuyer MA, Saint-Laurent O, Larochelle C, Darlington PJ, Arbour N, Antel JP, Kennedy TE, Prat A. Netrin 1 regulates blood-brain barrier function and neuroinflammation. Brain. 2015 Jun;138(Pt 6):1598-612. doi: 10.1093/brain/awv092.

Michell-Robinson MA, Touil H, Healy LM, Owen DR, Durafourt BA, Bar-Or A, Antel JP, Moore CS. Roles of microglia in brain development, tissue maintenance and repair. Brain. 2015 May;138(Pt 5):1138-59. doi: 10.1093/brain/awv066.

Moore CS, Ase AR, Kinsara A, Rao VT, Michell-Robinson M, Leong SY, Butovsky O, Ludwin SK, Séguéla P, Bar-Or A, Antel JP. P2Y12 expression and function in alternatively activated human microglia. Neurol Neuroimmunol Neuroinflamm. 2015 Mar 19;2(2):e80. doi: 10.1212/NXI.0000000000000080. eCollection 2015 Apr. Erratum in: Neurol Neuroimmunol Neuroinflamm. 2015 Jun;2(3):e106.

Lim TK, Shi XQ, Johnson JM, Rone MB, Antel JP, David S, Zhang J. Peripheral nerve injury induces persistent vascular dysfunction and endoneurial hypoxia, contributing to the genesis of neuropathic pain. J Neurosci. 2015 Feb 25;35(8):3346-59. doi: 10.1523/JNEUROSCI.4040-14.2015.

Moore CS, Cui QL, Warsi NM, Durafourt BA, Zorko N, Owen DR, Antel JP, Bar-Or A. Direct and indirect effects of immune and central nervous system-resident cells on human oligodendrocyte progenitor cell differentiation. J Immunol. 2015 Jan 15;194(2):761-72. doi: 10.4049/jimmunol.1401156.

Cao M, Cortes M, Moore CS, Leong SY, Durosier LD, Burns P, Fecteau G, Desrochers A, Auer RN, Barreiro LB, Antel JP, Frasch MG. Fetal microglial phenotype in vitro carries memory of prior in vivo exposure to inflammation. Front Cell Neurosci. 2015 Aug 4;9:294. doi: 10.3389/fncel.2015.00294. eCollection 2015.

Mayo L, Trauger SA, Blain M, Nadeau M, Patel B, Alvarez JI, Mascanfroni ID, Yeste A, Kivisäkk P, Kallas K, Ellezam B, Bakshi R, Prat A, Antel JP, Weiner HL, Quintana FJ. Regulation of astrocyte activation by glycolipids drives chronic CNS inflammation. Nat Med. 2014 Oct;20(10):1147-56. doi: 10.1038/nm.3681.

Cui QL, Fang J, Kennedy TE, Almazan G, Antel JP. Role of p38MAPK in S1P receptor-mediated differentiation of human oligodendrocyte progenitors. Glia. 2014 Aug;62(8):1361-75. doi: 10.1002/glia.22688. Epub 2014 May 9. PubMed PMID: 24810969.

Leong SY, Rao VT, Bin JM, Gris P, Sangaralingam M, Kennedy TE, Antel JP. Heterogeneity of oligodendrocyte progenitor cells in adult human brain. Ann Clin Transl Neurol. 2014 Apr;1(4):272-83. doi: 10.1002/acn3.55.

Miyazaki Y, Li R, Rezk A, Misirliyan H, Moore C, Farooqi N, Solis M, Goiry LG, de Faria Junior O, Dang VD, Colman D, Dhaunchak AS, Antel J, Gommerman J, Prat A, Fillatreau S, Bar-Or A; CIHR/MSSC New Emerging Team Grant in Clinical Autoimmunity; MSSRF Canadian B cells in MS Team. A novel microRNA-132-surtuin-1 axis underlies aberrant B-cell cytokine regulation in patients with relapsing-remitting multiple sclerosis. PLoS One. 2014 Aug 19;9(8):e105421. doi: 10.1371/journal.pone.0105421. eCollection 2014.

Butovsky O, Jedrychowski MP, Moore CS, Cialic R, Lanser AJ, Gabriely G, Koeglsperger T, Dake B, Wu PM, Doykan CE, Fanek Z, Liu L, Chen Z, Rothstein JD, Ransohoff RM, Gygi SP, Antel JP, Weiner HL. Identification of a unique TGF-β-dependent molecular and functional signature in microglia. Nat Neurosci. 2014 Jan;17(1):131-43. doi: 10.1038/nn.3599.

 

ARBOUR NATHALIE

Pickles S, Arbour N, Vande Velde C. Immunodetection of outer membrane proteins by flow cytometry of isolated mitochondria. J Vis Exp. 2014 Sep 18;(91):51887. doi: 10.3791/51887. PubMed PMID: 25285411.

Giacomini PS, Rozenberg A, Metz I, Araujo D, Arbour N, Bar-Or A; Maraviroc in Multiple Sclerosis–Associated PML–IRIS (MIMSAPI) Group. Maraviroc and JC virus-associated immune reconstitution inflammatory syndrome. N Engl J Med. 2014 Jan 30;370(5):486-8. doi: 10.1056/NEJMc1304828. PubMed PMID: 24476450.

Larochelle C, Lécuyer MA, Alvarez JI, Charabati M, Saint-Laurent O, Ghannam S, Kebir H, Flanagan K, Yednock T, Duquette P, Arbour N, Prat A. Melanoma cell adhesion molecule-positive CD8 T lymphocytes mediate central nervous system inflammation. Ann Neurol. 2015 Jul;78(1):39-53. doi: 10.1002/ana.24415.

Podjaski C, Alvarez JI, Bourbonniere L, Larouche S, Terouz S, Bin JM, Lécuyer MA, Saint-Laurent O, Larochelle C, Darlington PJ, Arbour N, Antel JP, Kennedy TE, Prat A. Netrin 1 regulates blood-brain barrier function and neuroinflammation. Brain. 2015 Jun;138(Pt 6):1598-612. doi: 10.1093/brain/awv092.

Legroux L, Pittet CL, Beauseigle D, Deblois G, Prat A, Arbour N. An optimized method to process mouse CNS to simultaneously analyze neural cells and leukocytes by flow cytometry. J Neurosci Methods. 2015 May 30;247:23-31. doi: 10.1016/j.jneumeth.2015.03.021.

 

ARNOLD DOUGLAS

Grover SA, Aubert-Broche B, Fetco D, Collins DL, Arnold DL, Finlayson M, Banwell BL, Motl RW, Yeh EA. Lower physical activity is associated with higher disease burden in pediatric multiple sclerosis. Neurology. 2015 Aug 12. pii: 10.1212/WNL.0000000000001939. [Epub ahead of print] PubMed PMID: 26268901.

Makhani N, Banwell B, Tellier R, Yea C, McGovern S, O’Mahony J, Ahorro JM, Arnold D, Sadovnick AD, Marrie RA, Bar-Or A; Canadian Pediatric Demyelinating Disease Network. Viral exposures and MS outcome in a prospective cohort of children with acquired demyelination. Mult Scler. 2015 Jul 21. pii: 1352458515595876. [Epub ahead of print] PubMed PMID: 26199356.

Rocca MA, Sonkin M, Copetti M, Pagani E, Arnold DL, Narayanan S, Sled JG, Banwell B, Filippi M. Diffusion tensor magnetic resonance imaging in very early onset pediatric multiple sclerosis. Mult Scler. 2015 Jul 21. pii: 1352458515596600. [Epub ahead of print] PubMed PMID: 26199355.

Karimaghaloo Z, Arnold DL, Arbel T. Adaptive multi-level conditional random fields for detection and segmentation of small enhanced pathology in medical images. Med Image Anal. 2015 Jul 11. pii: S1361-8415(15)00091-2. doi: 10.1016/j.media.2015.06.004. [Epub ahead of print] PubMed PMID: 26211811.

Schipper HM, Arnold D, GrandʼMaison F, Melmed C, Moore F, Levental M, Su H, Constantin M, Stril JL, Godin J. Tolerability and Safety of Combined Glatiramer Acetate and N-Acetylcysteine in Relapsing-Remitting Multiple Sclerosis. Clin Neuropharmacol. 2015 Jul-Aug;38(4):127-31. doi: 10.1097/WNF.0000000000000090. PubMed PMID: 26166235.

Kieseier BC, Arnold DL, Balcer LJ, Boyko AA, Pelletier J, Liu S, Zhu Y, Seddighzadeh A, Hung S, Deykin A, Sheikh SI, Calabresi PA. Peginterferon beta-1a in multiple sclerosis: 2-year results from ADVANCE. Mult Scler. 2015 Jul;21(8):1025-35. doi: 10.1177/1352458514557986. Epub 2014 Nov 28. PubMed PMID: 25432952; PubMed Central PMCID: PMC4512519.

Nakamura K, Brown RA, Narayanan S, Collins DL, Arnold DL; Alzheimer’s Disease Neuroimaging Initiative. Diurnal fluctuations in brain volume: Statistical analyses of MRI from large populations. Neuroimage. 2015 Jun 3;118:126-132. doi: 10.1016/j.neuroimage.2015.05.077. [Epub ahead of print] PubMed PMID: 26049148.

Karimaghaloo Z, Rivaz H, Arnold DL, Collins DL, Arbel T. Temporal Hierarchical Adaptive Texture CRF for Automatic Detection of Gadolinium-Enhancing Multiple Sclerosis Lesions in Brain MRI. IEEE Trans Med Imaging. 2015 Jun;34(6):1227-41. doi: 10.1109/TMI.2014.2382561. Epub 2014 Dec 18. PubMed PMID: 25532171.

Ghassemi R, Brown R, Banwell B, Narayanan S, Arnold DL; Canadian Pediatric Demyelinating Disease Study Group. Quantitative Measurement of tissue damage and recovery within new T2w lesions in pediatric- and adult-onset multiple sclerosis. Mult Scler. 2015 May;21(6):718-25. doi: 10.1177/1352458514551594. Epub 2014 Dec 5. PubMed PMID: 25480858.

Harmouche R, Subbanna NK, Collins DL, Arnold DL, Arbel T. Probabilistic multiple sclerosis lesion classification based on modeling regional intensity variability and local neighborhood information. IEEE Trans Biomed Eng. 2015 May;62(5):1281-92. doi: 10.1109/TBME.2014.2385635. Epub 2014 Dec 23. PubMed PMID: 25546852.

De Stefano N, Arnold DL. Towards a better understanding of pseudoatrophy in the brain of multiple sclerosis patients. Mult Scler. 2015 May;21(6):675-6. doi: 10.1177/1352458514564494. Epub 2015 Jan 26. PubMed PMID: 25623248.

Kappos L, Giovannoni G, Gold R, Phillips JT, Arnold DL, Hotermans C, Zhang A, Viglietta V, Fox RJ; DEFINE and CONFIRM study investigators. Time course of clinical and neuroradiological effects of delayed-release dimethyl fumarate in multiple sclerosis. Eur J Neurol. 2015 Apr;22(4):664-71. doi: 10.1111/ene.12624. Epub 2015 Jan 2. PubMed PMID: 25557371.

Ghassemi R, Brown R, Narayanan S, Banwell B, Nakamura K, Arnold DL. Normalization of white matter intensity on T1-weighted images of patients with acquired central nervous system demyelination. J Neuroimaging. 2015 Mar-Apr;25(2):184-90. doi: 10.1111/jon.12129. Epub 2014 Jun 19. PubMed PMID: 24942347.

Nash RA, Hutton GJ, Racke MK, Popat U, Devine SM, Griffith LM, Muraro PA, Openshaw H, Sayre PH, Stüve O, Arnold DL, Spychala ME, McConville KC, Harris KM, Phippard D, Georges GE, Wundes A, Kraft GH, Bowen JD. High-dose immunosuppressive therapy and autologous hematopoietic cell transplantation for relapsing-remitting multiple sclerosis (HALT-MS): a 3-year interim report. JAMA Neurol. 2015 Feb;72(2):159-69. doi: 10.1001/jamaneurol.2014.3780. PubMed PMID: 25546364.

Viglietta V, Miller D, Bar-Or A, Phillips JT, Arnold DL, Selmaj K, Kita M, Hutchinson M, Yang M, Zhang R, Dawson KT, Sheikh SI, Fox RJ, Gold R. Efficacy of delayed-release dimethyl fumarate in relapsing-remitting multiple sclerosis: integrated analysis of the phase 3 trials. Ann Clin Transl Neurol. 2015 Feb;2(2):103-18. doi: 10.1002/acn3.148. Epub 2014 Dec 4. PubMed PMID: 25750916; PubMed Central PMCID: PMC4338952.

Subbanna N, Precup D, Arnold D, Arbel T. IMaGe: Iterative Multilevel Probabilistic Graphical Model for Detection and Segmentation of Multiple Sclerosis Lesions in Brain MRI. Inf Process Med Imaging. 2015;24:514-26. PubMed PMID: 26221699.

Guizard N, Coupé P, Fonov VS, Manjón JV, Arnold DL, Collins DL. Rotation-invariant multi-contrast non-local means for MS lesion segmentation. Neuroimage Clin. 2015 May 13;8:376-89. doi: 10.1016/j.nicl.2015.05.001. eCollection 2015. PubMed PMID: 26106563; PubMed Central PMCID: PMC4474283.

Arnold DL, Calabresi PA, Kieseier BC, Sheikh SI, Deykin A, Zhu Y, Liu S, You X, Sperling B, Hung S. Effect of peginterferon beta-1a on MRI measures and achieving no evidence of disease activity: results from a randomized controlled trial in relapsing-remitting multiple sclerosis. BMC Neurol. 2014 Dec 31;14:240. doi: 10.1186/s12883-014-0240-x. PubMed PMID: 25551571; PubMed Central PMCID: PMC4311432.

Quintana FJ, Patel B, Yeste A, Nyirenda M, Kenison J, Rahbari R, Fetco D, Hussain M, O’Mahony J, Magalhaes S, McGowan M, Johnson T, Rajasekharan S, Narayanan S, Arnold DL, Weiner HL, Banwell B, Bar-Or A; Canadian Pediatric Demyelinating Disease Network. Epitope spreading as an early pathogenic event in pediatric multiple sclerosis. Neurology. 2014 Dec 9;83(24):2219-26. doi: 10.1212/WNL.0000000000001066. Epub 2014 Nov 7. PubMed PMID: 25381299; PubMed Central PMCID: PMC4277672.

Aubert-Broche B, Fonov V, Narayanan S, Arnold DL, Araujo D, Fetco D, Till C, Sled JG, Banwell B, Collins DL; Canadian Pediatric Demyelinating Disease Network. Onset of multiple sclerosis before adulthood leads to failure of age-expected brain growth. Neurology. 2014 Dec 2;83(23):2140-6. doi: 10.1212/WNL.0000000000001045. Epub 2014 Nov 5. PubMed PMID: 25378667; PubMed Central PMCID: PMC4276405.

Arnold DL, Gold R, Kappos L, Bar-Or A, Giovannoni G, Selmaj K, Yang M, Zhang R, Stephan M, Sheikh SI, Dawson KT. Magnetization transfer ratio in the delayed-release dimethyl fumarate DEFINE study. J Neurol. 2014 Dec;261(12):2429-37. doi: 10.1007/s00415-014-7504-7. Epub 2014 Oct 1. PubMed PMID: 25270680; PubMed Central PMCID: PMC4242981.

Arnold DL, Gold R, Kappos L, Bar-Or A, Giovannoni G, Selmaj K, Yang M, Zhang R, Stephan M, Sheikh SI, Dawson KT. Effects of delayed-release dimethyl fumarate on MRI measures in the Phase 3 DEFINE study. J Neurol. 2014 Sep;261(9):1794-802. doi: 10.1007/s00415-014-7412-x. Epub 2014 Jul 3. PubMed PMID: 24989666; PubMed Central PMCID: PMC4155185.

Derakhshan M, Caramanos Z, Narayanan S, Arnold DL, Louis Collins D. Surface-based analysis reveals regions of reduced cortical magnetization transfer ratio in patients with multiple sclerosis: a proposed method for imaging subpial demyelination. Hum Brain Mapp. 2014 Jul;35(7):3402-13. doi: 10.1002/hbm.22410. Epub 2013 Dec 4. PubMed PMID: 24356893.

Calabresi PA, Kieseier BC, Arnold DL, Balcer LJ, Boyko A, Pelletier J, Liu S, Zhu Y, Seddighzadeh A, Hung S, Deykin A; ADVANCE Study Investigators. Pegylated interferon β-1a for relapsing-remitting multiple sclerosis (ADVANCE): a randomised, phase 3, double-blind study. Lancet Neurol. 2014 Jul;13(7):657-65. doi: 10.1016/S1474-4422(14)70068-7. Epub 2014 Apr 30. PubMed PMID: 24794721.

Vollmer TL, Sorensen PS, Selmaj K, Zipp F, Havrdova E, Cohen JA, Sasson N, Gilgun-Sherki Y, Arnold DL; BRAVO Study Group. A randomized placebo-controlled phase III trial of oral laquinimod for multiple sclerosis. J Neurol. 2014 Apr;261(4):773-83. doi: 10.1007/s00415-014-7264-4. Epub 2014 Feb 18. PubMed PMID: 24535134.

Leppert IR, Narayanan S, Araújo D, Giacomini PS, Lapierre Y, Arnold DL, Pike GB. Interpreting therapeutic effect in multiple sclerosis via MRI contrast enhancing lesions: now you see them, now you don’t. J Neurol. 2014 Apr;261(4):809-16. doi: 10.1007/s00415-014-7284-0. Epub 2014 Feb 26. PubMed PMID: 24570281.

Trojan DA, Narayanan S, Francis SJ, Caramanos Z, Robinson A, Cardoso M, Arnold DL. Brain volume and fatigue in patients with postpoliomyelitis syndrome. PM R. 2014 Mar;6(3):215-20. doi: 10.1016/j.pmrj.2013.09.009. Epub 2013 Sep 20. PubMed PMID: 24060387.

Sormani MP, Arnold DL, De Stefano N. Reply: To PMID 24006277. Ann Neurol. 2014 Mar;75(3):463-4. doi: 10.1002/ana.24111. Epub 2014 Mar 7. PubMed PMID: 24493445.

Kappos L, Gold R, Arnold DL, Bar-Or A, Giovannoni G, Selmaj K, Sarda SP, Agarwal S, Zhang A, Sheikh SI, Seidman E, Dawson KT. Quality of life outcomes with BG-12 (dimethyl fumarate) in patients with relapsing-remitting multiple sclerosis: the DEFINE study. Mult Scler. 2014 Feb;20(2):243-52. doi: 10.1177/1352458513507817. Epub 2013 Oct 22. PubMed PMID: 24150779.

Giacomini PS, Rozenberg A, Metz I, Araujo D, Arbour N, Bar-Or A; Maraviroc in Multiple Sclerosis–Associated PML–IRIS (MIMSAPI) Group. Maraviroc and JC virus-associated immune reconstitution inflammatory syndrome. N Engl J Med. 2014 Jan 30;370(5):486-8. doi: 10.1056/NEJMc1304828. PubMed PMID: 24476450.

Sormani MP, Arnold DL, De Stefano N. Treatment effect on brain atrophy correlates with treatment effect on disability in multiple sclerosis. Ann Neurol. 2014 Jan;75(1):43-9. doi: 10.1002/ana.24018. Epub 2014 Jan 2. PubMed PMID: 24006277.

Nakamura K, Guizard N, Fonov VS, Narayanan S, Collins DL, Arnold DL. Jacobian integration method increases the statistical power to measure gray matter atrophy in multiple sclerosis. Neuroimage Clin. 2013 Oct 29;4:10-7. doi: 10.1016/j.nicl.2013.10.015. eCollection 2014. PubMed PMID: 24266007; PubMed Central PMCID: PMC3830061.

Ghassemi R, Narayanan S, Banwell B, Sled JG, Shroff M, Arnold DL; Canadian Pediatric Demyelinating Disease Network. Quantitative determination of regional lesion volume and distribution in children and adults with relapsing-remitting multiple sclerosis. PLoS One. 2014 Feb 26;9(2):e85741. doi: 10.1371/journal.pone.0085741. eCollection 2014. PubMed PMID: 24586244; PubMed Central PMCID: PMC3935826.

Nakamura K, Brown RA, Araujo D, Narayanan S, Arnold DL. Correlation between brain volume change and T2 relaxation time induced by dehydration and rehydration: implications for monitoring atrophy in clinical studies. Neuroimage Clin. 2014 Aug 23;6:166-70. doi: 10.1016/j.nicl.2014.08.014. eCollection 2014. PubMed PMID: 25379428; PubMed Central PMCID: PMC4215533.

Brown RA, Narayanan S, Banwell B, Arnold DL; Canadian Pediatric Demyelinating Disease Network. Magnetization transfer ratio recovery in new lesions decreases during adolescence in pediatric-onset multiple sclerosis patients. Neuroimage Clin. 2014 Sep 10;6:237-42. doi: 10.1016/j.nicl.2014.09.003. eCollection 2014. PubMed PMID: 25379436; PubMed Central PMCID: PMC4215523.

Brown RA, Narayanan S, Arnold DL. Imaging of repeated episodes of demyelination and remyelination in multiple sclerosis. Neuroimage Clin. 2014 Aug 15;6:20-5. doi: 10.1016/j.nicl.2014.06.009. eCollection 2014. PubMed PMID: 25610760; PubMed Central PMCID: PMC4299955.

 

BAR-OR AMIT

Makhani N, Banwell B, Tellier R, Yea C, McGovern S, O’Mahony J, Ahorro JM, Arnold D, Sadovnick AD, Marrie RA, Bar-Or A; Canadian Pediatric Demyelinating Disease Network. Viral exposures and MS outcome in a prospective cohort of children with acquired demyelination. Mult Scler. 2015 Jul 21. pii: 1352458515595876.

Mery V, Kimoff RJ, Suarez I, Benedetti A, Kaminska M, Robinson A, Lapierre Y, Bar-Or A, Trojan DA. High false-positive rate of questionnaire-based restless legs syndrome diagnosis in multiple sclerosis. Sleep Med. 2015 Jul;16(7):877-82. doi: 10.1016/j.sleep.2015.02.529.

O’Mahony J, Marrie RA, Laporte A, Yeh EA, Bar-Or A, Phan C, Buckley D, Callen D, Connolly MB, Pohl D, Dilenge ME, Bernard G, Lortie A, Lowry N, MacDonald EA, Meek D, Sébire G, Venkateswaran S, Wood E, Yager J, Banwell B. Recovery From Central Nervous System Acute Demyelination in Children. Pediatrics. 2015 Jul;136(1):e115-23. doi: 10.1542/peds.2015-0028.

Nyirenda MH, Morandi E, Vinkemeier U, Constantin-Teodosiu D, Drinkwater S, Mee M, King L, Podda G, Zhang GX, Ghaemmaghami A, Constantinescu CS, Bar-Or A, Gran B. TLR2 stimulation regulates the balance between regulatory T cell and Th17 function: a novel mechanism of reduced regulatory T cell function in multiple sclerosis. J Immunol. 2015 Jun 15;194(12):5761-74. doi: 10.4049/jimmunol.1400472.

Ahn JJ, O’Mahony J, Moshkova M, Hanwell HE, Singh H, Zhang MA, Marrie RA, Bar-Or A, Sadovnick DA, Dunn SE, Banwell BL. Puberty in females enhances the risk of an outcome of multiple sclerosis in children and the development of central nervous system autoimmunity in mice. Mult Scler. 2015 May;21(6):735-48. doi: 10.1177/1352458514551453.

Bin Dhuban K, d’Hennezel E, Nashi E, Bar-Or A, Rieder S, Shevach EM, Nagata S, Piccirillo CA. Coexpression of TIGIT and FCRL3 identifies Helios+ human memory regulatory T cells. J Immunol. 2015 Apr 15;194(8):3687-96. doi: 10.4049/jimmunol.1401803.

Bar-Or A, Wiendl H, Miller B, Benamor M, Truffinet P, Church M, Menguy-Vacheron F. Randomized study of teriflunomide effects on immune responses to neoantigen and recall antigens. Neurol Neuroimmunol Neuroinflamm. 2015 Feb 12;2(2):e70. doi: 10.1212/NXI.0000000000000070. eCollection 2015 Apr.

Moore CS, Ase AR, Kinsara A, Rao VT, Michell-Robinson M, Leong SY, Butovsky O, Ludwin SK, Séguéla P, Bar-Or A, Antel JP. P2Y12 expression and function in alternatively activated human microglia. Neurol Neuroimmunol Neuroinflamm. 2015 Mar 19;2(2):e80. doi: 10.1212/NXI.0000000000000080. eCollection 2015 Apr. Erratum in: Neurol Neuroimmunol Neuroinflamm. 2015 Jun;2(3):e106.

Miller DH, Fox RJ, Phillips JT, Hutchinson M, Havrdova E, Kita M, Wheeler-Kingshott CA, Tozer DJ, MacManus DG, Yousry TA, Goodsell M, Yang M, Zhang R, Viglietta V, Dawson KT; CONFIRM study investigators. Effects of delayed-release dimethyl fumarate on MRI measures in the phase 3 CONFIRM study. Neurology. 2015 Mar 17;84(11):1145-52. doi: 10.1212/WNL.0000000000001360.

Villar LM, Costa-Frossard L, Masterman T, Fernandez O, Montalban X, Casanova B, Izquierdo G, Coret F, Tumani H, Saiz A, Arroyo R, Fink K, Leyva L, Espejo C, Simó-Castelló M, García-Sánchez MI, Lauda F, Llufriú S, Álvarez-Lafuente R, Olascoaga J, Prada A, Oterino A, de Andrés C, Tintoré M, Ramió-Torrentà L, Rodríguez-Martín E, Picón C, Comabella M, Quintana E, Agüera E, Díaz S, Fernandez-Bolaños R, García-Merino JA, Landete L, Menéndez-González M, Navarro L, Pérez D, Sánchez-López F, Serrano-Castro PJ, Tuñón A, Espiño M, Muriel A, Bar-Or A, Álvarez-Cermeño JC. Lipid-specific immunoglobulin M bands in cerebrospinal fluid are associated with a reduced risk of developing progressive multifocal leukoencephalopathy during treatment with natalizumab. Ann Neurol. 2015 Mar;77(3):447-57. doi: 10.1002/ana.24345.

Stork L, Brück W, Bar-Or A, Metz I. High CCR5 expression in natalizumab-associated progressive multifocal leukoencephalopathy immune reconstitution inflammatory syndrome supports treatment with the CCR5 inhibitor maraviroc. Acta Neuropathol. 2015 Mar;129(3):467-8. doi: 10.1007/s00401-015-1391-6.

Viglietta V, Miller D, Bar-Or A, Phillips JT, Arnold DL, Selmaj K, Kita M, Hutchinson M, Yang M, Zhang R, Dawson KT, Sheikh SI, Fox RJ, Gold R. Efficacy of delayed-release dimethyl fumarate in relapsing-remitting multiple sclerosis: integrated analysis of the phase 3 trials. Ann Clin Transl Neurol. 2015 Feb;2(2):103-18. doi: 10.1002/acn3.148.

Moore CS, Cui QL, Warsi NM, Durafourt BA, Zorko N, Owen DR, Antel JP, Bar-Or A. Direct and indirect effects of immune and central nervous system-resident cells on human oligodendrocyte progenitor cell differentiation. J Immunol. 2015 Jan 15;194(2):761-72. doi: 10.4049/jimmunol.1401156.

Quintana FJ, Patel B, Yeste A, Nyirenda M, Kenison J, Rahbari R, Fetco D, Hussain M, O’Mahony J, Magalhaes S, McGowan M, Johnson T, Rajasekharan S, Narayanan S, Arnold DL, Weiner HL, Banwell B, Bar-Or A; Canadian Pediatric Demyelinating Disease Network. Epitope spreading as an early pathogenic event in pediatric multiple sclerosis. Neurology. 2014 Dec 9;83(24):2219-26. doi: 10.1212/WNL.0000000000001066.

Amrom D, Kinay D, Hart Y, Berkovic SF, Laxer K, Andermann F, Andermann E, Bar-Or A. Rasmussen encephalitis and comorbid autoimmune diseases: A window into disease mechanism? Neurology. 2014 Sep 16;83(12):1049-55. doi: 10.1212/WNL.0000000000000791. Epub 2014 Aug 20.

Arnold DL, Gold R, Kappos L, Bar-Or A, Giovannoni G, Selmaj K, Yang M, Zhang R, Stephan M, Sheikh SI, Dawson KT. Effects of delayed-release dimethyl fumarate on MRI measures in the Phase 3 DEFINE study. J Neurol. 2014 Sep;261(9):1794-802. doi: 10.1007/s00415-014-7412-x. Epub 2014 Jul 3.

Villar LM, Casanova B, Ouamara N, Comabella M, Jalili F, Leppert D, de Andrés C, Izquierdo G, Arroyo R, Avşar T, Lapin SV, Johnson T, Montalbán X, Fernández O, Álvarez-Lafuente R, Masterman D, García-Sánchez MI, Coret F, Siva A, Evdoshenko E, Álvarez-Cermeño JC, Bar-Or A. Immunoglobulin M oligoclonal bands: biomarker of targetable inflammation in primary progressive multiple sclerosis. Ann Neurol. 2014 Aug;76(2):231-40. doi: 10.1002/ana.24190.

Shen P, Roch T, Lampropoulou V, O’Connor RA, Stervbo U, Hilgenberg E, Ries S, Dang VD, Jaimes Y, Daridon C, Li R, Jouneau L, Boudinot P, Wilantri S, Sakwa I, Miyazaki Y, Leech MD, McPherson RC, Wirtz S, Neurath M, Hoehlig K, Meinl E, Grützkau A, Grün JR, Horn K, Kühl AA, Dörner T, Bar-Or A, Kaufmann SH, Anderton SM, Fillatreau S. IL-35-producing B cells are critical regulators of immunity during autoimmune and infectious diseases. Nature. 2014 Mar 20;507(7492):366-70. doi: 10.1038/nature12979.

Sato DK, Nakashima I, Bar-Or A, Misu T, Suzuki C, Nishiyama S, Kuroda H, Fujihara K, Aoki M. Changes in Th17 and regulatory T cells after fingolimod initiation to treat multiple sclerosis. J Neuroimmunol. 2014 Mar 15;268(1-2):95-8. doi: 10.1016/j.jneuroim.2014.01.008.

Zastepa E, Fitz-Gerald L, Hallett M, Antel J, Bar-Or A, Baranzini S, Lapierre Y, Haegert DG. Naive CD4 T-cell activation identifies MS patients having rapid transition to progressive MS. Neurology. 2014 Feb 25;82(8):681-90. doi: 10.1212/WNL.0000000000000146. Epub 2014 Jan 22. Erratum in: Neurology. 2014 Apr 1;82(13):1193.

Kappos L, Gold R, Arnold DL, Bar-Or A, Giovannoni G, Selmaj K, Sarda SP, Agarwal S, Zhang A, Sheikh SI, Seidman E, Dawson KT. Quality of life outcomes with BG-12 (dimethyl fumarate) in patients with relapsing-remitting multiple sclerosis: the DEFINE study. Mult Scler. 2014 Feb;20(2):243-52. doi: 10.1177/1352458513507817.

Cited in PMCRelated citationsGiacomini PS, Rozenberg A, Metz I, Araujo D, Arbour N, Bar-Or A; Maraviroc in Multiple Sclerosis–Associated PML–IRIS (MIMSAPI) Group. Maraviroc and JC virus-associated immune reconstitution inflammatory syndrome. N Engl J Med. 2014 Jan 30;370(5):486-8. doi: 10.1056/NEJMc1304828.

Miyazaki Y, Li R, Rezk A, Misirliyan H, Moore C, Farooqi N, Solis M, Goiry LG, de Faria Junior O, Dang VD, Colman D, Dhaunchak AS, Antel J, Gommerman J, Prat A, Fillatreau S, Bar-Or A; CIHR/MSSC New Emerging Team Grant in Clinical Autoimmunity; MSSRF Canadian B cells in MS Team. A novel microRNA-132-surtuin-1 axis underlies aberrant B-cell cytokine regulation in patients with relapsing-remitting multiple sclerosis. PLoS One. 2014 Aug 19;9(8):e105421. doi: 10.1371/journal.pone.0105421. eCollection 2014.

Posevitz-Fejfár A, Posevitz V, Gross CC, Bhatia U, Kurth F, Schütte V, Bar-Or A, Meuth SG, Wiendl H. Effects of blood transportation on human peripheral mononuclear cell yield, phenotype and function: implications for immune cell biobanking. PLoS One. 2014 Dec 26;9(12):e115920. doi: 10.1371/journal.pone.0115920. eCollection 2014.

 

DAVID SAMUEL

Kwon BK, Streijger F, Hill CE, Anderson AJ, Bacon M, Beattie MS, Blesch A, Bradbury EJ, Brown A, Bresnahan JC, Case CC, Colburn RW, David S, Fawcett JW, Ferguson AR, Fischer I, Floyd CL, Gensel JC, Houle JD, Jakeman LB, Jeffery ND, Jones LA, Kleitman N, Kocsis J, Lu P, Magnuson DS, Marsala M, Moore SW, Mothe AJ, Oudega M, Plant GW, Rabchevsky AS, Schwab JM, Silver J, Steward O, Xu XM, Guest JD, Tetzlaff W. Large animal and primate models of spinal cord injury for the testing of novel therapies. Exp Neurol. 2015 Jul;269:154-68. doi: 10.1016/j.expneurol.2015.04.008..

Jiang R, Hua C, Wan Y, Jiang B, Hu H, Zheng J, Fuqua BK, Dunaief JL, Anderson GJ, David S, Vulpe CD, Chen H. Hephaestin and ceruloplasmin play distinct but interrelated roles in iron homeostasis in mouse brain. J Nutr. 2015 May;145(5):1003-9. doi: 10.3945/jn.114.207316.

Zarruk JG, Berard JL, Passos Dos Santos R, Kroner A, Lee J, Arosio P, David S. Expression of iron homeostasis proteins in the spinal cord in experimental autoimmune encephalomyelitis and their implications for iron accumulation. Neurobiol Dis. 2015 Feb 25. pii: S0969-9961(15)00021-2. doi: 10.1016/j.nbd.2015.02.001.  In press.

Lim TK, Shi XQ, Johnson JM, Rone MB, Antel JP, David S, Zhang J. Peripheral nerve injury induces persistent vascular dysfunction and endoneurial hypoxia, contributing to the genesis of neuropathic pain. J Neurosci. 2015 Feb 25;35(8):3346-59. doi: 10.1523/JNEUROSCI.4040-14.2015.

David, S. and Popovich, P.G (2014). Microglial responses to spinal cord and brain trauma.  In: Microglia. In: Microglia in health and disease (Eds. Marie-Ève Tremblay and Amanda Sierra), Springer.\

Kroner A, Greenhalgh AD, Zarruk JG, Passos Dos Santos R, Gaestel M, David S. TNF and increased intracellular iron alter macrophage polarization to a detrimental M1 phenotype in the injured spinal cord. Neuron. 2014 Sep 3;83(5):1098-116. doi: 10.1016/j.neuron.2014.07.027.

Lemmon VP, Ferguson AR, Popovich PG, Xu XM, Snow DM, Igarashi M, Beattie CE, Bixby JL; MIASCI Consortium. Minimum information about a spinal cord injury experiment: a proposed reporting standard for spinal cord injury experiments. J Neurotrauma. 2014 Aug 1;31(15):1354-61. doi: 10.1089/neu.2014.3400.

Gresle MM, Schulz K, Jonas A, Perreau VM, Cipriani T, Baxter AG, Miranda-Hernandez S, Field J, Jokubaitis VG, Cherny R, Volitakis I, David S, Kilpatrick TJ, Butzkueven H. Ceruloplasmin gene-deficient mice with experimental autoimmune encephalomyelitis show attenuated early disease evolution. J Neurosci Res. 2014 Jun;92(6):732-42. doi: 10.1002/jnr.23349.

Greenhalgh AD, David S. Differences in the phagocytic response of microglia and peripheral macrophages after spinal cord injury and its effects on cell death. J Neurosci. 2014 Apr 30;34(18):6316-22. doi: 10.1523/JNEUROSCI.4912-13.2014.

 

DUQUETTE PIERRE

Shahrbanian S, Duquette P, Ahmed S, Mayo NE. Pain acts through fatigue to affect participation in individuals with multiple sclerosis. Qual Life Res. 2015 Aug 9. In  Press.

Kalincik T, Jokubaitis V, Izquierdo G, Duquette P, Girard M, Grammond P, Lugaresi A, Oreja-Guevara C, Bergamaschi R, Hupperts R, Grand’Maison F, Pucci E, Van Pesch V, Boz C, Iuliano G, Fernandez-Bolanos R, Flechter S, Spitaleri D, Cristiano E, Verheul F, Lechner-Scott J, Amato MP, Cabrera-Gomez JA, Saladino ML, Slee M, Moore F, Gray O, Paine M, Barnett M, Havrdova E, Horakova D, Spelman T, Trojano M, Butzkueven H; MSBase Study Group. Comparative effectiveness of glatiramer acetate and interferon beta formulations in relapsing-remitting multiple sclerosis. Mult Scler. 2015 Aug;21(9):1159-71. doi: 10.1177/1352458514559865.

Warrender-Sparkes M, Spelman T, Izquierdo G, Trojano M, Lugaresi A, Grand’Maison F, Havrdova E, Horakova D, Boz C, Oreja-Guevara C, Alroughani R, Iuliano G, Duquette P, Girard M, Terzi M, Hupperts R, Grammond P, Petersen T, Fernandez-Bolaños R, Fiol M, Pucci E, Lechner-Scott J, Verheul F, Cristiano E, Van Pesch V, Petkovska-Boskova T, Moore F, Kister I, Bergamaschi R, Saladino ML, Slee M, Barnett M, Amato MP, Shaw C, Shuey N, Young C, Gray O, Kappos L, Butzkueven H, Kalincik T, Jokubaitis V; MSBase study group. The effect of oral immunomodulatory therapy on treatment uptake and persistence in multiple sclerosis. Mult Scler. 2015 Jul 21. pii: 1352458515594041. In Press.

Larochelle C, Lécuyer MA, Alvarez JI, Charabati M, Saint-Laurent O, Ghannam S, Kebir H, Flanagan K, Yednock T, Duquette P, Arbour N, Prat A. Melanoma cell adhesion molecule-positive CD8 T lymphocytes mediate central nervous system inflammation. Ann Neurol. 2015 Jul;78(1):39-53. doi: 10.1002/ana.24415.

Bergamaschi R, Montomoli C, Mallucci G, Lugaresi A, Izquierdo G, Grand’Maison F, Duquette P, Shaygannejad V, Alroughani R, Grammond P, Boz C, Iuliano G, Zwanikken C, Petersen T, Lechner-Scott J, Hupperts R, Butzkueven H, Pucci E, Oreja-Guevara C, Cristiano E, Pia Amato MP, Havrdova E, Fernandez-Bolanos R, Spelman T, Trojano M. BREMSO: a simple score to predict early the natural course of multiple sclerosis. Eur J Neurol. 2015 Jun;22(6):981-9. doi: 10.1111/ene.12696.

Jokubaitis VG, Spelman T, Kalincik T, Izquierdo G, Grand’Maison F, Duquette P, Girard M, Lugaresi A, Grammond P, Hupperts R, Cabrera-Gomez J, Oreja-Guevara C, Boz C, Giuliani G, Fernández-Bolaños R, Iuliano G, Lechner-Scott J, Verheul F, van Pesch V, Petkovska-Boskova T, Fiol M, Moore F, Cristiano E, Alroughani R, Bergamaschi R, Barnett M, Slee M, Vella N, Herbert J, Shaw C, Saladino ML, Amato MP, Liew D, Paolicelli D, Butzkueven H, Trojano M. Predictors of disability worsening in clinically isolated syndrome. Ann Clin Transl Neurol. 2015 May;2(5):479-91. doi: 10.1002/acn3.187.

He A, Spelman T, Jokubaitis V, Havrdova E, Horakova D, Trojano M, Lugaresi A, Izquierdo G, Grammond P, Duquette P, Girard M, Pucci E, Iuliano G, Alroughani R, Oreja-Guevara C, Fernandez-Bolaños R, Grand’Maison F, Sola P, Spitaleri D, Granella F, Terzi M, Lechner-Scott J, Van Pesch V, Hupperts R, Sánchez-Menoyo JL, Hodgkinson S, Rozsa C, Verheul F, Butzkueven H, Kalincik T; MSBase Study Group. Comparison of switch to fingolimod or interferon beta/glatiramer acetate in active multiple sclerosis. JAMA Neurol. 2015 Apr;72(4):405-13. doi: 10.1001/jamaneurol.2014.4147.

Spelman T, Kalincik T, Zhang A, Pellegrini F, Wiendl H, Kappos L, Tsvetkova L, Belachew S, Hyde R, Verheul F, Grand-Maison F, Izquierdo G, Grammond P, Duquette P, Lugaresi A, Lechner-Scott J, Oreja-Guevara C, Hupperts R, Petersen T, Barnett M, Trojano M, Butzkueven H. Comparative efficacy of switching to natalizumab in active multiple sclerosis. Ann Clin Transl Neurol. 2015 Apr;2(4):373-87. doi: 10.1002/acn3.180.

Shahrbanian S, Duquette P, Kuspinar A, Mayo NE. Contribution of symptom clusters to multiple sclerosis consequences. Qual Life Res. 2015 Mar;24(3):617-29. doi: 10.1007/s11136-014-0804-7.

Kalincik T, Horakova D, Spelman T, Jokubaitis V, Trojano M, Lugaresi A, Izquierdo G, Rozsa C, Grammond P, Alroughani R, Duquette P, Girard M, Pucci E, Lechner-Scott J, Slee M, Fernandez-Bolanos R, Grand’Maison F, Hupperts R, Verheul F, Hodgkinson S, Oreja-Guevara C, Spitaleri D, Barnett M, Terzi M, Bergamaschi R, McCombe P, Sanchez-Menoyo J, Simo M, Csepany T, Rum G, Boz C, Havrdova E, Butzkueven H; MSBase Study Group. Switch to natalizumab versus fingolimod in active relapsing-remitting multiple sclerosis. Ann Neurol. 2015 Mar;77(3):425-35. doi: 10.1002/ana.24339.

Duquette P, Prat A. How safe is natalizumab during pregnancy? Mult Scler. 2015 Feb;21(2):121-2. doi: 10.1177/1352458514555789.

Ribbons KA, McElduff P, Boz C, Trojano M, Izquierdo G, Duquette P, Girard M, Grand’Maison F, Hupperts R, Grammond P, Oreja-Guevara C, Petersen T, Bergamaschi R, Giuliani G, Barnett M, van Pesch V, Amato MP, Iuliano G, Fiol M, Slee M, Verheul F, Cristiano E, Fernandez-Bolanos R, Saladino ML, Rio ME, Cabrera-Gomez J, Butzkueven H, van Munster E, Den Braber-Moerland L, La Spitaleri D, Lugaresi A, Shaygannejad V, Gray O, Deri N, Alroughani R, Lechner-Scott J. Male Sex Is Independently Associated with Faster Disability Accumulation in Relapse-Onset MS but Not in Primary Progressive MS. PLoS One. 2015 Jun 5;10(6):e0122686. doi: 10.1371/journal.pone.0122686. eCollection 2015.

Spelman T, Gray O, Trojano M, Petersen T, Izquierdo G, Lugaresi A, Hupperts R, Bergamaschi R, Duquette P, Grammond P, Giuliani G, Boz C, Verheul F, Oreja-Guevara C, Barnett M, Grand’Maison F, Edite Rio M, Lechner-Scott J, Van Pesch V, Fernandez Bolanos R, Flechter S, Den Braber-Moerland L, Iuliano G, Amato MP, Slee M, Cristiano E, Saladino ML, Paine M, Vella N, Kasa K, Deri N, Herbert J, Moore F, Petkovska-Boskova T, Alroughani R, Savino A, Shaw C, Vucic S, Santiago V, Bacile EA, Skromne E, Poehlau D, Cabrera-Gomez JA, Lucas R, Butzkueven H. Seasonal variation of relapse rate in multiple sclerosis is latitude dependent. Ann Neurol. 2014 Dec;76(6):880-90. doi: 10.1002/ana.24287.

Bhan V, Lapierre Y, Freedman MS, Duquette P, Selchen D, Migounov V, Walt L, Zhang A. Anti-JC Virus Antibody Prevalence in Canadian MS Patients. Can J Neurol Sci. 2014 Nov;41(6):748-52. doi: 10.1017/cjn.2014.32.

Kalincik T, Buzzard K, Jokubaitis V, Trojano M, Duquette P, Izquierdo G, Girard M, Lugaresi A, Grammond P, Grand’Maison F, Oreja-Guevara C, Boz C, Hupperts R, Petersen T, Giuliani G, Iuliano G, Lechner-Scott J, Barnett M, Bergamaschi R, Van Pesch V, Amato MP, van Munster E, Fernandez-Bolanos R, Verheul F, Fiol M, Cristiano E, Slee M, Rio ME, Spitaleri D, Alroughani R, Gray O, Saladino ML, Flechter S, Herbert J, Cabrera-Gomez JA, Vella N, Paine M, Shaw C, Moore F, Vucic S, Savino A, Singhal B, Petkovska-Boskova T, Parratt J, Sirbu CA, Rozsa C, Liew D, Butzkueven H; MSBase Study Group. Risk of relapse phenotype recurrence in multiple sclerosis. Mult Scler. 2014 Oct;20(11):1511-22. doi: 10.1177/1352458514528762.

Calabresi PA, Kieseier BC, Arnold DL, Balcer LJ, Boyko A, Pelletier J, Liu S, Zhu Y, Seddighzadeh A, Hung S, Deykin A; ADVANCE Study Investigators. Pegylated interferon β-1a for relapsing-remitting multiple sclerosis (ADVANCE): a randomised, phase 3, double-blind study. Lancet Neurol. 2014 Jul;13(7):657-65. doi: 10.1016/S1474-4422(14)70068-7.

Karp I, Manganas A, Sylvestre MP, Ho A, Roger E, Duquette P. Does pregnancy alter the long-term course of multiple sclerosis? Ann Epidemiol. 2014 Jul;24(7):504-8.e2. doi: 10.1016/j.annepidem.2014.04.007.

Hughes SE, Spelman T, Gray OM, Boz C, Trojano M, Lugaresi A, Izquierdo G, Duquette P, Girard M, Grand’Maison F, Grammond P, Oreja-Guevara C, Hupperts R, Bergamaschi R, Giuliani G, Lechner-Scott J, Barnett M, Edite Rio M, van Pesch V, Amato MP, Iuliano G, Slee M, Verheul F, Cristiano E, Fernández-Bolaños R, Poehlau D, Saladino ML, Deri N, Cabrera-Gomez J, Vella N, Herbert J, Skromne E, Savino A, Shaw C, Moore F, Vucic S, Petkovska-Boskova T, McDonnell G, Hawkins S, Kee F, Butzkueven H; MSBase study group. Predictors and dynamics of postpartum relapses in women with multiple sclerosis. Mult Scler. 2014 May;20(6):739-46. doi: 10.1177/1352458513507816.

Jokubaitis VG, Li V, Kalincik T, Izquierdo G, Hodgkinson S, Alroughani R, Lechner-Scott J, Lugaresi A, Duquette P, Girard M, Barnett M, Grand’Maison F, Trojano M, Slee M, Giuliani G, Shaw C, Boz C, Spitaleri DL, Verheul F, Haartsen J, Liew D, Butzkueven H; MSBase Study Group. Fingolimod after natalizumab and the risk of short-term relapse. Neurology. 2014 Apr 8;82(14):1204-11. doi: 10.1212/WNL.0000000000000283. Epub 2014 Mar 7.

Kang H, Metz LM, Traboulsee AL, Eliasziw M, Zhao GJ, Cheng Y, Zhao Y, Li DK; Minocycline in CIS Study Group. Application and a proposed modification of the 2010 McDonald criteria for the diagnosis of multiple sclerosis in a Canadian cohort of patients with clinically isolated syndromes. Mult Scler. 2014 Apr;20(4):458-63. doi: 10.1177/1352458513501230.

Kalincik T, Vivek V, Jokubaitis V, Lechner-Scott J, Trojano M, Izquierdo G, Lugaresi A, Grand’maison F, Hupperts R, Oreja-Guevara C, Bergamaschi R, Iuliano G, Alroughani R, Van Pesch V, Amato MP, Slee M, Verheul F, Fernandez-Bolanos R, Fiol M, Spitaleri DL, Cristiano E, Gray O, Cabrera-Gomez JA, Shaygannejad V, Herbert J, Vucic S, Needham M, Petkovska-Boskova T, Sirbu CA, Duquette P, Girard M, Grammond P, Boz C, Giuliani G, Rio ME, Barnett M, Flechter S, Moore F, Singhal B, Bacile EA, Saladino ML, Shaw C, Skromne E, Poehlau D, Vella N, Spelman T, Liew D, Kilpatrick TJ, Butzkueven H; MSBase Study Group. Sex as a determinant of relapse incidence and progressive course of multiple sclerosis. Brain. 2013 Dec;136(Pt 12):3609-17. doi: 10.1093/brain/awt281.

Mowry EM, Carey RF, Blasco MR, Pelletier J, Duquette P, Villoslada P, Malikova I, Roger E, Kinkel RP, McDonald J, Bacchetti P, Waubant E. Multiple sclerosis susceptibility genes: associations with relapse severity and recovery. PLoS One. 2013 Oct 9;8(10):e75416. doi: 10.1371/journal.pone.0075416. eCollection 2013.

Mowry EM, Carey RF, Blasco MR, Pelletier J, Duquette P, Villoslada P, Malikova I, Roger E, Kinkel RP, McDonald J, Bacchetti P, Waubant E. Association of multiple sclerosis susceptibility variants and early attack location in the CNS. PLoS One. 2013 Oct 10;8(10):e75565. doi: 10.1371/journal.pone.0075565. eCollection 2013.

 

FOURNIER SYLVIE

Van Den Ham KM, Shio MT, Rainone A, Fournier S, Krawczyk CM, Olivier M. Iron prevents the development of experimental cerebral malaria by attenuating CXCR3-mediated T cell chemotaxis. PLoS One. 2015 Mar 13;10(3):e0118451. doi: 10.1371/journal.pone.0118451. eCollection 2015.

Contreras I, Estrada JA, Guak H, Martel C, Borjian A, Ralph B, Shio MT, Fournier S, Krawczyk CM, Olivier M. Impact of Leishmania mexicana infection on dendritic cell signaling and functions.PLoS Negl Trop Dis. 2014 Sep 25;8(9):e3202. doi: 10.1371/journal.pntd.0003202. eCollection 2014 Sep.

Yang M, Rainone A, Shi XQ, Fournier S, Zhang J. A new animal model of spontaneous autoimmune peripheral polyneuropathy: implications for Guillain-Barré syndrome. Acta Neuropathol Commun. 2014 Jan 8;2:5. doi: 10.1186/2051-5960-2-5.

 

JOOBER RIDHA

Hovington CL, Bodnar M, Chakravarty MM, Joober R, Malla AK, Lepage M. Investigation of white matter abnormalities in first episode psychosis patients with persistent negative symptoms. Psychiatry Res. 2015 Sep 30;233(3):402-8. doi: 10.1016/j.pscychresns.2015.06.017.

Buchy L, Hawco C, Joober R, Malla A, Lepage M. Cognitive insight in first-episode schizophrenia: Further evidence for a role of the ventrolateral prefrontal cortex. Schizophr Res. 2015 Aug;166(1-3):65-8. doi: 10.1016/j.schres.2015.05.009.

Rho A, Traicu A, Lepage M, Iyer SN, Malla A, Joober R. Clinical and functional implications of a history of childhood ADHD in first-episode psychosis. Schizophr Res. 2015 Jul;165(2-3):128-33. doi: 10.1016/j.schres.2015.03.031. Iyer S, Jordan G, MacDonald K, Joober R, Malla A. Early intervention for psychosis: a Canadian perspective. J Nerv Ment Dis. 2015 May;203(5):356-64. doi: 10.1097/NMD.0000000000000288. Review.

Malla A, Joober R, Garcia A. “Mental illness is like any other medical illness”: a critical examination of the statement and its impact on patient care and society. J Psychiatry Neurosci. 2015 May;40(3):147-50.

Booij L, Casey KF, Antunes JM, Szyf M, Joober R, Israël M, Steiger H. DNA methylation in individuals with anorexia nervosa and in matched normal-eater controls: A genome-wide study. Int J Eat Disord. 2015 Mar 23. doi: 10.1002/eat.22374. In Press.

Levy E, Traicu A, Iyer S, Malla A, Joober R. Psychotic disorders comorbid with attention-deficit hyperactivity disorder: an important knowledge gap. Can J Psychiatry. 2015 Mar 1;60(3 Suppl 2):S48-52.

Lutgens D, Iyer S, Joober R, Brown TG, Norman R, Latimer E, Schmitz N, Abdel Baki A, Abadi S, Malla A. A five-year randomized parallel and blinded clinical trial of an extended specialized early intervention vs. regular care in the early phase of psychotic disorders: study protocol. BMC Psychiatry. 2015 Feb 14;15:22. doi: 10.1186/s12888-015-0404-2.

Sengupta SM, Fortier MÈ, Thakur GA, Bhat V, Grizenko N, Joober R. Parental psychopathology in families of children with attention-deficit/hyperactivity disorder and exposed to maternal smoking during pregnancy. J Child Psychol Psychiatry. 2015 Feb;56(2):122-9. doi: 10.1111/jcpp.12286.

Lyne J, Joober R, Schmitz N, Lepage M, Malla A. Duration of active psychosis and first-episode psychosis negative symptoms.Early Interv Psychiatry. 2015 Jan 13. doi: 10.1111/eip.12217. In Press.

Pruessner M, Lepage M, Collins DL, Pruessner JC, Joober R, Malla AK. Reduced hippocampal volume and hypothalamus-pituitary-adrenal axis function in first episode psychosis: evidence for sex differences. Neuroimage Clin. 2014 Dec 5;7:195-202. doi: 10.1016/j.nicl.2014.12.001. eCollection 2015.

Hawco C, Buchy L, Bodnar M, Izadi S, Dell’Elce J, Messina K, Joober R, Malla A, Lepage M. Source retrieval is not properly differentiated from object retrieval in early schizophrenia: an fMRI study using virtual reality. Neuroimage Clin. 2014 Aug 13;7:336-46. doi: 10.1016/j.nicl.2014.08.006. eCollection 2015..

Girard SL, Dion PA, Bourassa CV, Geoffroy S, Lachance-Touchette P, Barhdadi A, Langlois M, Joober R, Krebs MO, Dubé MP, Rouleau GA. Mutation burden of rare variants in schizophrenia candidate genes. PLoS One. 2015 Jun 3;10(6):e0128988. doi: 10.1371/journal.pone.0128988. eCollection 2015.

Tibbo P, Malla A, Manchanda R, Williams R, Joober R. Relapse risk assessment in early phase psychosis: the search for a reliable and valid tool. Can J Psychiatry. 2014 Dec;59(12):655-8. Review.

Malla A, Jordan G, Joober R, Schmitz N, Norman R, Brown T, Goldberg K, Loohuis H, Vracotas N, Rochford J. A controlled evaluation of a targeted early case detection intervention for reducing delay in treatment of first episode psychosis. Soc Psychiatry Psychiatr Epidemiol. 2014 Nov;49(11):1711-8. doi: 10.1007/s00127-014-0893-1.

Ellenbogen MA, Linnen AM, Cardoso C, Joober R. Intranasal oxytocin attenuates the human acoustic startle response independent of emotional modulation. Psychophysiology. 2014 Nov;51(11):1169-77. doi: 10.1111/psyp.12263.

Thaler L, Gauvin L, Joober R, Groleau P, de Guzman R, Ambalavanan A, Israel M, Wilson S, Steiger H. Methylation of BDNF in women with bulimic eating syndromes: associations with childhood abuse and borderline personality disorder. Prog Neuropsychopharmacol Biol Psychiatry. 2014 Oct 3;54:43-9. doi: 10.1016/j.pnpbp.2014.04.010.

Joober R. Medium range cognitive impairment (MeRCI) hypothesis for psychosis formation: evidence from epidemiological studies and recent molecular genetic developments. J Psychiatry Neurosci. 2014 Jul;39(4):219-22.

Jordan G, Lutgens D, Joober R, Lepage M, Iyer SN, Malla A. The relative contribution of cognition and symptomatic remission to functional outcome following treatment of a first episode of psychosis. J Clin Psychiatry. 2014 Jun;75(6):e566-72. doi: 10.4088/JCP.13m08606.

Cherkasova MV, Faridi N, Casey KF, O’Driscoll GA, Hechtman L, Joober R, Baker GB, Palmer J, Dagher A, Leyton M, Benkelfat C. Amphetamine-induced dopamine release and neurocognitive function in treatment-naive adults with ADHD.Neuropsychopharmacology. 2014 May;39(6):1498-507. doi: 10.1038/npp.2013.349.

Benoit A, Bodnar M, Malla AK, Joober R, Bherer L, Lepage M. Changes in memory performance over a 12-month period in relation to achieving symptomatic remission after a first-episode psychosis. Schizophr Res. 2014 Mar;153(1-3):103-8. doi: 10.1016/j.schres.2014.01.024.

Lutgens D, Malla A, Joober R, Iyer S. The impact of caregiver familiarity with mental disorders on timing of intervention in first-episode psychosis. Early Interv Psychiatry. 2014 Jan 29. doi: 10.1111/eip.12121. In Press.

Albanna A, Choudhry Z, Harvey PO, Fathalli F, Cassidy C, Sengupta SM, Iyer SN, Rho A, Lepage M, Malla A, Joober R. TCF4 gene polymorphism and cognitive performance in patients with first episode psychosis. Schizophr Res. 2014 Jan;152(1):124-9. doi: 10.1016/j.schres.2013.10.038.

Bodnar M, Hovington CL, Buchy L, Malla AK, Joober R, Lepage M. Cortical thinning in temporo-parietal junction (TPJ) in non-affective first-episode of psychosis patients with persistent negative symptoms. PLoS One. 2014 Jun 30;9(6):e101372. doi: 10.1371/journal.pone.0101372. eCollection 2014.

 

LUHESHI GIAMAL

Aguilar-Valles A, Inoue W, Rummel C, Luheshi GN. Obesity, adipokines and neuroinflammation. Neuropharmacology. 2015 Sep;96(Pt A):124-34. doi: 10.1016/j.neuropharm.2014.12.023.

Veru F, Dancause K, Laplante DP, King S, Luheshi G. Prenatal maternal stress predicts reductions in CD4+ lymphocytes, increases in innate-derived cytokines, and a Th2 shift in adolescents: Project Ice Storm. Physiol Behav. 2015 May 15;144:137-45. doi: 10.1016/j.physbeh.2015.03.016.

Aguilar-Valles A, Kim J, Jung S, Woodside B, Luheshi GN. Role of brain transmigrating neutrophils in depression-like behavior during systemic infection. Mol Psychiatry. 2015 Mar;20(3):413-4. doi: 10.1038/mp.2014.173.

Castanon N, Luheshi G, Layé S. Role of neuroinflammation in the emotional and cognitive alterations displayed by animal models of obesity. Front Neurosci. 2015 Jul 3;9:229. doi: 10.3389/fnins.2015.00229. eCollection 2015.

Pohl J, Woodside B, Luheshi GN. Leptin modulates the late fever response to LPS in diet-induced obese animals. Brain Behav Immun. 2014 Nov;42:41-7. doi: 10.1016/j.bbi.2014.07.017.

Lim TK, Shi XQ, Martin HC, Huang H, Luheshi G, Rivest S, Zhang J. Blood-nerve barrier dysfunction contributes to the generation of neuropathic pain and allows targeting of injured nerves for pain relief. Pain. 2014 May;155(5):954-67. doi: 10.1016/j.pain.2014.01.026.

Aguilar-Valles A, Kim J, Jung S, Woodside B, Luheshi GN. Role of brain transmigrating neutrophils in depression-like behavior during systemic infection. Mol Psychiatry. 2014 May;19(5):599-606. doi: 10.1038/mp.2013.137. Epub 2013 Oct 15. Erratum in: Mol Psychiatry. 2014 May;19(5):633. Aguliar-Valles, A [corrected to Aguilar-Valles]. Mol Psychiatry. 2015 Mar;20(3):413-4.

Veru F, Laplante DP, Luheshi G, King S. Prenatal maternal stress exposure and immune function in the offspring.Stress. 2014 Mar;17(2):133-48. doi: 10.3109/10253890.2013.876404.

Koenig S, Luheshi GN, Wenz T, Gerstberger R, Roth J, Rummel C. Leptin is involved in age-dependent changes in response to systemic inflammation in the rat. Brain Behav Immun. 2014 Feb;36:128-38.

Maric T, Woodside B, Luheshi GN. The effects of dietary saturated fat on basal hypothalamic neuroinflammation in rats. Brain Behav Immun. 2014 Feb;36:35-45. doi: 10.1016/j.bbi.2013.09.011.

Pohl J, Sheppard M, Luheshi GN, Woodside B. Diet-induced weight gain produces a graded increase in behavioral responses to an acute immune challenge. Brain Behav Immun. 2014 Jan;35:43-50. doi: 10.1016/j.bbi.2013.09.002.

 

MAYO NANCY

Shahrbanian S, Duquette P, Ahmed S, Mayo NE. Pain acts through fatigue to affect participation in individuals with multiple sclerosis. Qual Life Res. 2015 Aug 9. In Press.

Barbic SP, Bartlett SJ, Mayo NE. Emotional vitality in caregivers: application of Rasch Measurement Theory with secondary data to development and test a new measure. Clin Rehabil. 2015 Jul;29(7):705-16. doi: 10.1177/0269215514552503.

Aburub AS, Gagnon B, Rodríguez AM, Mayo NE. Using a personalized measure (Patient Generated Index (PGI)) to identify what matters to people with cancer. Support Care Cancer. 2015 Jun 23. In Press.

Lee L, Dumitra T, Fiore JF Jr, Mayo NE, Feldman LS. How well are we measuring postoperative “recovery” after abdominal surgery? Qual Life Res. 2015 May 24. In Press.

Mayo NE, Scott SC, Bernstein CN, Lix LM. How are you? Do people with inflammatory bowel disease experience response shift on this question? Health Qual Life Outcomes. 2015 May 6;13:52. doi: 10.1186/s12955-015-0232-6.

Goldberg MS, Wheeler AJ, Burnett RT, Mayo NE, Valois MF, Brophy JM, Giannetti N. Physiological and perceived health effects from daily changes in air pollution and weather among persons with heart failure: a panel study. J Expo Sci Environ Epidemiol. 2015 Mar-Apr;25(2):187-99. doi: 10.1038/jes.2014.43.

Shahrbanian S, Duquette P, Kuspinar A, Mayo NE. Contribution of symptom clusters to multiple sclerosis consequences. Qual Life Res. 2015 Mar;24(3):617-29. doi: 10.1007/s11136-014-0804-7.

Sajobi TT, Lix LM, Singh G, Lowerison M, Engbers J, Mayo NE. Identifying reprioritization response shift in a stroke caregiver population: a comparison of missing data methods. Qual Life Res. 2015 Mar;24(3):529-40. doi: 10.1007/s11136-014-0824-3.

Mayo NE, Anderson S, Barclay R, Cameron JI, Desrosiers J, Eng JJ, Huijbregts M, Kagan A, Lyons MM, Moriello C, Richards CL, Salbach NM, Scott SC, Teasell R, Bayley M. Getting on with the rest of your life following stroke: A randomized trial of a complex intervention aimed at enhancing life participation post stroke. Clin Rehabil. 2015 Jan 27. pii: 0269215514565396. In Press.

Mayo NE, Scott SC, Bayley M, Cheung A, Garland J, Jutai J, Wood-Dauphinee S. Modeling health-related quality of life in people recovering from stroke. Qual Life Res. 2015 Jan;24(1):41-53. doi: 10.1007/s11136-013-0605-4.

Figueiredo S, Mayo NE. What pilot studies tell us! Disabil Rehabil. 2015;37(18):1694-5. doi: 10.3109/09638288.2015.1043471.

Barbic SP, Mayo NE, White CL, Bartlett SJ. Emotional vitality in family caregivers: content validation of a theoretical framework.Qual Life Res. 2014 Dec;23(10):2865-72. doi: 10.1007/s11136-014-0718-4.

Mayo NE, Moriello C, Scott SC, Dawes D, Auais M, Chasen M. Pedometer-facilitated walking intervention shows promising effectiveness for reducing cancer fatigue: a pilot randomized trial. Clin Rehabil. 2014 Dec;28(12):1198-209. doi: 10.1177/0269215514536209.

Antonescu I, Carli F, Mayo NE, Feldman LS. Validation of the SF-36 as a measure of postoperative recovery after colorectal surgery. Surg Endosc. 2014 Nov;28(11):3168-78. doi: 10.1007/s00464-014-3577-8.

Rosenzveig A, Kuspinar A, Daskalopoulou SS, Mayo NE. Toward patient-centered care: a systematic review of how to ask questions that matter to patients. Medicine (Baltimore). 2014 Nov;93(22):e120. doi: 10.1097/MD.0000000000000120. Review.

Kuspinar A, Mayo NE. A review of the psychometric properties of generic utility measures in multiple sclerosis.Pharmacoeconomics. 2014 Aug;32(8):759-73. doi: 10.1007/s40273-014-0167-5. Review.

Antonescu I, Scott S, Tran TT, Mayo NE, Feldman LS. Measuring postoperative recovery: what are clinically meaningful differences? Surgery. 2014 Aug;156(2):319-27. doi: 10.1016/j.surg.2014.03.005.

Tran TT, Kaneva P, Mayo NE, Fried GM, Feldman LS. Short-stay surgery: what really happens after discharge? Surgery. 2014 Jul;156(1):20-7. doi: 10.1016/j.surg.2014.03.024.

Kuspinar A, Finch L, Pickard S, Mayo NE. Using existing data to identify candidate items for a health state classification system in multiple sclerosis. Qual Life Res. 2014 Jun;23(5):1445-57. doi: 10.1007/s11136-013-0604-5.

Antonescu I, Mueller CL, Fried GM, Vassiliou MC, Mayo NE, Feldman LS. Outcomes reported in high-impact surgical journals. Br J Surg. 2014 Apr;101(5):582-9. doi: 10.1002/bjs.9450.

Mayo NE, Bronstein D, Scott SC, Finch LE, Miller S. Necessary and sufficient causes of participation post-stroke: practical and philosophical perspectives. Qual Life Res. 2014 Feb;23(1):39-47. doi: 10.1007/s11136-013-0441-6.

Lee L, Tran T, Mayo NE, Carli F, Feldman LS. What does it really mean to “recover” from an operation? Surgery. 2014 Feb;155(2):211-6. doi: 10.1016/j.surg.2013.10.002.

Neville A, Lee L, Antonescu I, Mayo NE, Vassiliou MC, Fried GM, Feldman LS. Systematic review of outcomes used to evaluate enhanced recovery after surgery. Br J Surg. 2014 Feb;101(3):159-70. doi: 10.1002/bjs.9324. Review.

Nobel L, Mayo NE, Hanley J, Nadeau L, Daskalopoulou SS. MyRisk_Stroke Calculator: A Personalized Stroke Risk Assessment Tool for the General Population. J Clin Neurol. 2014 Jan;10(1):1-9. doi: 10.3988/jcn.2014.10.1.1.

Vadnerkar A, Figueiredo S, Mayo NE, Kearney RE. Classification of gait quality for biofeedback to improve heel-to-toe gait. Conf Proc IEEE Eng Med Biol Soc. 2014;2014:3626-9. doi: 10.1109/EMBC.2014.6944408.

 

NALBANTOGLU JOSEPHINE

Chen H, Nalbantoglu J. Ring cell migration assay identifies distinct effects of extracellular matrix proteins on cancer cell migration. BMC Res Notes. 2014 Mar 27;7:183. doi: 10.1186/1756-0500-7-183.

 

PICCIRILLO CIRIACO

Bin Dhuban K, d’Hennezel E, Nashi E, Bar-Or A, Rieder S, Shevach EM, Nagata S, Piccirillo CA. Coexpression of TIGIT and FCRL3 identifies Helios+ human memory regulatory T cells. J Immunol. 2015 Apr 15;194(8):3687-96. doi: 10.4049/jimmunol.1401803.

Blagih J, Coulombe F, Vincent EE, Dupuy F, Galicia-Vázquez G, Yurchenko E, Raissi TC, van der Windt GJ, Viollet B, Pearce EL, Pelletier J, Piccirillo CA, Krawczyk CM, Divangahi M, Jones RG. The energy sensor AMPK regulates T cell metabolic adaptation and effector responses in vivo. Immunity. 2015 Jan 20;42(1):41-54. doi: 10.1016/j.immuni.2014.12.030.

Kornete M, Mason ES, Girouard J, Lafferty EI, Qureshi S, Piccirillo CA. Th1-Like ICOS+ Foxp3+ Treg Cells Preferentially Express CXCR3 and Home to β-Islets during Pre-Diabetes in BDC2.5 NOD Mice. PLoS One. 2015 May 6;10(5):e0126311. doi: 10.1371/journal.pone.0126311. eCollection 2015.

Pagliari D, Piccirillo CA, Larbi A, Cianci R. The Interactions between Innate Immunity and Microbiota in Gastrointestinal Diseases. J Immunol Res. 2015;2015:898297. doi: 10.1155/2015/898297. Epub 2015 May 20.

Massoud AH, Kaufman GN, Piccirillo CA, Mazer BD. Reply: To PMID 24210883. J Allergy Clin Immunol. 2014 Dec;134(6):1469-70. doi: 10.1016/j.jaci.2014.08.050.

Lafferty EI, Flaczyk A, Angers I, Homer R, d’Hennezel E, Malo D, Piccirillo CA, Vidal SM, Qureshi ST. An ENU-induced splicing mutation reveals a role for Unc93b1 in early immune cell activation following influenza A H1N1 infection. Genes Immun. 2014 Jul-Aug;15(5):320-32. doi: 10.1038/gene.2014.22.

Piccirillo CA, Bjur E, Topisirovic I, Sonenberg N, Larsson O. Translational control of immune responses: from transcripts to translatomes. Nat Immunol. 2014 Jun;15(6):503-11. doi: 10.1038/ni.2891. Review.

Bin Dhuban K, Kornete M, S Mason E, Piccirillo CA. Functional dynamics of Foxp3⁺ regulatory T cells in mice and humans.Immunol Rev. 2014 May;259(1):140-58. doi: 10.1111/imr.12168. Review.

Massoud AH, Yona M, Xue D, Chouiali F, Alturaihi H, Ablona A, Mourad W, Piccirillo CA, Mazer BD. Dendritic cell immunoreceptor: a novel receptor for intravenous immunoglobulin mediates induction of regulatory T cells. J Allergy Clin Immunol. 2014 Mar;133(3):853-63.e5. doi: 10.1016/j.jaci.2013.09.029.

Zouk H, D’Hennezel E, Du X, Ounissi-Benkalha H, Piccirillo CA, Polychronakos C. Functional evaluation of the role of C-type lectin domain family 16A at the chromosome 16p13 locus. Clin Exp Immunol. 2014 Mar;175(3):485-97. doi: 10.1111/cei.12240.

 

PRAT ALEXANDRE

Larochelle C, Lécuyer MA, Alvarez JI, Charabati M, Saint-Laurent O, Ghannam S, Kebir H, Flanagan K, Yednock T, Duquette P, Arbour N, Prat A. Melanoma cell adhesion molecule-positive CD8 T lymphocytes mediate central nervous system inflammation. Ann Neurol. 2015 Jul;78(1):39-53. doi: 10.1002/ana.24415.

Podjaski C, Alvarez JI, Bourbonniere L, Larouche S, Terouz S, Bin JM, Lécuyer MA, Saint-Laurent O, Larochelle C, Darlington PJ, Arbour N, Antel JP, Kennedy TE, Prat A. Netrin 1 regulates blood-brain barrier function and neuroinflammation. Brain. 2015 Jun;138(Pt 6):1598-612. doi: 10.1093/brain/awv092.

Legroux L, Pittet CL, Beauseigle D, Deblois G, Prat A, Arbour N. An optimized method to process mouse CNS to simultaneously analyze neural cells and leukocytes by flow cytometry. J Neurosci Methods. 2015 May 30;247:23-31. doi: 10.1016/j.jneumeth.2015.03.021.

Michel L, Larochelle C, Prat A. Update on treatments in multiple sclerosis. Presse Med. 2015 Apr;44(4 Pt 2):e137-51. doi: 10.1016/j.lpm.2015.02.008.

Duquette P, Prat A. How safe is natalizumab during pregnancy? Mult Scler. 2015 Feb;21(2):121-2. doi: 10.1177/1352458514555789.

Alvarez JI, Saint-Laurent O, Godschalk A, Terouz S, Briels C, Larouche S, Bourbonnière L, Larochelle C, Prat A. Focal disturbances in the blood-brain barrier are associated with formation of neuroinflammatory lesions. Neurobiol Dis. 2015 Feb;74:14-24. doi: 10.1016/j.nbd.2014.09.016.

Daneman R, Prat A. The blood-brain barrier. Cold Spring Harb Perspect Biol. 2015 Jan 5;7(1):a020412. doi: 10.1101/cshperspect.a020412.

Larochelle C, Grand’maison F, Bernier GP, Latour M, Cailhier JF, Prat A. Thrombotic thrombocytopenic purpura-hemolytic uremic syndrome in relapsing-remitting multiple sclerosis patients on high-dose interferon β. Mult Scler. 2014 Nov;20(13):1783-7. doi: 10.1177/1352458514523692.

Mayo L, Trauger SA, Blain M, Nadeau M, Patel B, Alvarez JI, Mascanfroni ID, Yeste A, Kivisäkk P, Kallas K, Ellezam B, Bakshi R, Prat A, Antel JP, Weiner HL, Quintana FJ. Regulation of astrocyte activation by glycolipids drives chronic CNS inflammation. Nat Med. 2014 Oct;20(10):1147-56. doi: 10.1038/nm.3681..

Aubé B, Lévesque SA, Paré A, Chamma É, Kébir H, Gorina R, Lécuyer MA, Alvarez JI, De Koninck Y, Engelhardt B, Prat A, Côté D, Lacroix S. Neutrophils mediate blood-spinal cord barrier disruption in demyelinating neuroinflammatory diseases. J Immunol. 2014 Sep 1;193(5):2438-54. doi: 10.4049/jimmunol.1400401.

Miyazaki Y, Li R, Rezk A, Misirliyan H, Moore C, Farooqi N, Solis M, Goiry LG, de Faria Junior O, Dang VD, Colman D, Dhaunchak AS, Antel J, Gommerman J, Prat A, Fillatreau S, Bar-Or A; CIHR/MSSC New Emerging Team Grant in Clinical Autoimmunity; MSSRF Canadian B cells in MS Team. A novel microRNA-132-surtuin-1 axis underlies aberrant B-cell cytokine regulation in patients with relapsing-remitting multiple sclerosis. PLoS One. 2014 Aug 19;9(8):e105421. doi: 10.1371/journal.pone.0105421. eCollection 2014.

 

TALBOT PIERRE

Desforges M, Le Coupanec A, Stodola JK, Meessen-Pinard M, Talbot PJ. Human coronaviruses: viral and cellular factors involved in neuroinvasiveness and neuropathogenesis. Virus Res. 2014 Dec 19;194:145-58. doi: 10.1016/j.virusres.2014.09.011.

Brison E, Jacomy H, Desforges M, Talbot PJ. Novel treatment with neuroprotective and antiviral properties against a neuroinvasive human respiratory virus. J Virol. 2014 Feb;88(3):1548-63. doi: 10.1128/JVI.02972-13.

Desforges M, Le Coupanec A, Brison E, Meessen-Pinard M, Talbot PJ. Neuroinvasive and neurotropic human respiratory coronaviruses: potential neurovirulent agents in humans. Adv Exp Med Biol. 2014;807:75-96. doi: 10.1007/978-81-322-1777-0_6. Review.

 

WOLFSON CHRISTINA

Goulden R, Ibrahim T, Wolfson C. Is high socioeconomic status a risk factor for multiple sclerosis? A systematic review. Eur J Neurol. 2015 Jun;22(6):899-911. doi: 10.1111/ene.12586.

Bjørnevik K, Riise T, Cortese M, Holmøy T, Kampman MT, Magalhaes S, Myhr KM, Wolfson C, Pugliatti M. Level of education and multiple sclerosis risk after adjustment for known risk factors: The EnvIMS study. Mult Scler. 2015 May 26. pii: 1352458515579444.

Cortese M, Riise T, Bjørnevik K, Holmøy T, Kampman MT, Magalhaes S, Pugliatti M, Wolfson C, Myhr KM. Timing of use of cod liver oil, a vitamin D source, and multiple sclerosis risk: The EnvIMS study. Mult Scler. 2015 May 6. pii: 1352458515578770.

Ragnedda G, Leoni S, Parpinel M, Casetta I, Riise T, Myhr KM, Wolfson C, Pugliatti M. Reduced duration of breastfeeding is associated with a higher risk of multiple sclerosis in both Italian and Norwegian adult males: the EnvIMS study. J Neurol. 2015 May;262(5):1271-7. doi: 10.1007/s00415-015-7704-9.

Wesnes K, Riise T, Casetta I, Drulovic J, Granieri E, Holmøy T, Kampman MT, Landtblom AM, Lauer K, Lossius A, Magalhaes S, Pekmezovic T, Bjørnevik K, Wolfson C, Pugliatti M, Myhr KM. Body size and the risk of multiple sclerosis in Norway and Italy: the EnvIMS study. Mult Scler. 2015 Apr;21(4):388-95. doi: 10.1177/1352458514546785.

Griffith LE, van den Heuvel E, Fortier I, Sohel N, Hofer SM, Payette H, Wolfson C, Belleville S, Kenny M, Doiron D, Raina P. Statistical approaches to harmonize data on cognitive measures in systematic reviews are rarely reported. J Clin Epidemiol. 2015 Feb;68(2):154-62. doi: 10.1016/j.jclinepi.2014.09.003.

Magalhaes S, Pugliatti M, Casetta I, Drulovic J, Granieri E, Holmøy T, Kampman MT, Landtblom AM, Lauer K, Myhr KM, Parpinel M, Pekmezovic T, Riise T, Wolfson D, Zhu B, Wolfson C. The EnvIMS Study: Design and Methodology of an International Case-Control Study of Environmental Risk Factors in Multiple Sclerosis. Neuroepidemiology. 2015;44(3):173-81. doi: 10.1159/000381779.

Asgharian M, Wolfson C, Wolfson D (2014). “Analysis of Biased Survival Data: The Canadian Study of Health and Aging and Beyond”, Statistics in Action: A Canadian Outlook.  Edited by Jerald F. Lawless.  CRC Press, Taylor & Francis Group. The Statistical Society of Canada. Chapter 12: 193-208.

Keezer MR, Bouma HK, Wolfson C. The diagnostic accuracy of screening questionnaires for the identification of adults with epilepsy: a systematic review. Epilepsia. 2014 Nov;55(11):1772-80. doi: 10.1111/epi.12811. Epub 2014 Nov 6. Review.

Keezer MR, Pelletier A, Stechysin B, Veilleux M, Jetté N, Wolfson C. The diagnostic test accuracy of a screening questionnaire and algorithm in the identification of adults with epilepsy. Epilepsia. 2014 Nov;55(11):1763-71. doi: 10.1111/epi.12805.

Marrie RA, Fisk JD, Stadnyk KJ, Tremlett H, Wolfson C, Warren S, Bhan V, Yu BN; CIHR Team in the Epidemiology and Impact of Comorbidity on Multiple Sclerosis. Performance of administrative case definitions for comorbidity in multiple sclerosis in Manitoba and Nova Scotia. Chronic Dis Inj Can. 2014 Jul;34(2-3):145-53. English, French.

Ferini-Strambi L, Oertel W, Dauvilliers Y, Postuma RB, Marelli S, Iranzo A, Arnulf I, Högl B, Manni R, Miyamoto T, Fantini ML, Puligheddu M, Jennum P, Sonka K, Santamaria J, Zucconi M, Rancoita PM, Leu-Semenescu S, Frauscher B, Terzaghi M, Miyamoto M, Unger M, Stiasny-Kolster K, Desautels A, Wolfson C, Pelletier A, Montplaisir J. Autonomic symptoms in idiopathic REM behavior disorder: a multicentre case-control study.J Neurol. 2014 Jun;261(6):1112-8. doi: 10.1007/s00415-014-7317-8. Epub 2014 Apr 1. Erratum in: J Neurol. 2015 Jan;262(1):249-50. Birgit, Högl [corrected to Högl, Birgit].

Frauscher B, Jennum P, Ju YE, Postuma RB, Arnulf I, Cochen De Cock V, Dauvilliers Y, Fantini ML, Ferini-Strambi L, Gabelia D, Iranzo A, Leu-Semenescu S, Mitterling T, Miyamoto M, Miyamoto T, Montplaisir JY, Oertel W, Pelletier A, Prunetti P, Puligheddu M, Santamaria J, Sonka K, Unger M, Wolfson C, Zucconi M, Terzaghi M, Högl B, Mayer G, Manni R. Comorbidity and medication in REM sleep behavior disorder: a multicenter case-control study. Neurology. 2014 Mar 25;82(12):1076-9. doi: 10.1212/WNL.0000000000000247.

 

ZHANG JI

Zhang(2015). Peripheral and central immune mechanisms in neuropathic pain, Chapter 7, 109-121, Neuroinflammation: New Insights into Beneficial and Detrimental Functions, Wiley.

Sorge RE, Mapplebeck JC, Rosen S, Beggs S, Taves S, Alexander JK, Martin LJ, Austin JS, Sotocinal SG, Chen D, Yang M, Shi XQ, Huang H, Pillon NJ, Bilan PJ, Tu Y, Klip A, Ji RR, Zhang J, Salter MW, Mogil JS. Different immune cells mediate mechanical pain hypersensitivity in male and female mice. Nat Neurosci. 2015 Aug;18(8):1081-3. doi: 10.1038/nn.4053.

Lim TK, Shi XQ, Johnson JM, Rone MB, Antel JP, David S, Zhang J. Peripheral nerve injury induces persistent vascular dysfunction and endoneurial hypoxia, contributing to the genesis of neuropathic pain. J Neurosci. 2015 Feb 25;35(8):3346-59. doi: 10.1523/JNEUROSCI.4040-14.2015.

Zhang J, Echeverry S, Lim TK, Lee SH, Shi XQ, Huang H. Can modulating inflammatory response be a good strategy to treat neuropathic pain? Curr Pharm Des. 2015;21(7):831-9.

Lim TK, Shi XQ, Martin HC, Huang H, Luheshi G, Rivest S, Zhang J. Blood-nerve barrier dysfunction contributes to the generation of neuropathic pain and allows targeting of injured nerves for pain relief. Pain. 2014 May;155(5):954-67. doi: 10.1016/j.pain.2014.01.026.

Yang M, Rainone A, Shi XQ, Fournier S, Zhang J. A new animal model of spontaneous autoimmune peripheral polyneuropathy: implications for Guillain-Barré syndrome. Acta Neuropathol Commun. 2014 Jan 8;2:5. doi: 10.1186/2051-5960-2-5.