Antel, Jack MD

Professor

McGill University, Montreal Neurological Institute
3801 University Street, room 111, Montreal, QC H3A 2B4
514-398-3413
(514) 398-7371

Research Profile

The research program focuses on using human neural and immune cells to understand how their interactions can contribute to development of neurologic disease, specifically multiple sclerosis. The studies include how immune cells reach the central nervous system, how the state of activity of the endogenous glial cells contributes to persistence of the immune response, and how the immune mediators actually induce injury of the target cells, names oligodendrocytes and neurons and their processes. The corollary of these studies is to understand how the nervous system is able to repair itself from such injury.

Expertise

Interests include interactions between the immune and central nervous systems and inflammatory demyelinating disorders, including multiple sclerosis.

Recent Publications

  • Preisner A, Albrecht S, Cui QL, Hucke S, Ghelman J, Hartmann C, Taketo MM, Antel J, Klotz L, Kuhlmann T. Non-steroidal anti-inflammatory drug indometacin enhances endogenous remyelination. Acta Neuropathol. 2015 Aug;130(2):247-61. doi: 10.1007/s00401-015-1426-z.
  • Podjaski C, Alvarez JI, Bourbonniere L, Larouche S, Terouz S, Bin JM, Lécuyer MA, Saint-Laurent O, Larochelle C, Darlington PJ, Arbour N, Antel JP, Kennedy TE, Prat A. Netrin 1 regulates blood-brain barrier function and neuroinflammation. Brain. 2015 Jun;138(Pt 6):1598-612. doi: 10.1093/brain/awv092.
  • Michell-Robinson MA, Touil H, Healy LM, Owen DR, Durafourt BA, Bar-Or A, Antel JP, Moore CS. Roles of microglia in brain development, tissue maintenance and repair. Brain. 2015 May;138(Pt 5):1138-59. doi: 10.1093/brain/awv066.
  • Moore CS, Ase AR, Kinsara A, Rao VT, Michell-Robinson M, Leong SY, Butovsky O, Ludwin SK, Séguéla P, Bar-Or A, Antel JP. P2Y12 expression and function in alternatively activated human microglia. Neurol Neuroimmunol Neuroinflamm. 2015 Mar 19;2(2):e80. doi: 10.1212/NXI.0000000000000080. eCollection 2015 Apr. Erratum in: Neurol Neuroimmunol Neuroinflamm. 2015 Jun;2(3):e106.
  • Lim TK, Shi XQ, Johnson JM, Rone MB, Antel JP, David S, Zhang J. Peripheral nerve injury induces persistent vascular dysfunction and endoneurial hypoxia, contributing to the genesis of neuropathic pain. J Neurosci. 2015 Feb 25;35(8):3346-59. doi: 10.1523/JNEUROSCI.4040-14.2015.
  • Moore CS, Cui QL, Warsi NM, Durafourt BA, Zorko N, Owen DR, Antel JP, Bar-Or A. Direct and indirect effects of immune and central nervous system-resident cells on human oligodendrocyte progenitor cell differentiation. J Immunol. 2015 Jan 15;194(2):761-72. doi: 10.4049/jimmunol.1401156.
  • Cao M, Cortes M, Moore CS, Leong SY, Durosier LD, Burns P, Fecteau G, Desrochers A, Auer RN, Barreiro LB, Antel JP, Frasch MG. Fetal microglial phenotype in vitro carries memory of prior in vivo exposure to inflammation. Front Cell Neurosci. 2015 Aug 4;9:294. doi: 10.3389/fncel.2015.00294. eCollection 2015.
  • Mayo L, Trauger SA, Blain M, Nadeau M, Patel B, Alvarez JI, Mascanfroni ID, Yeste A, Kivisäkk P, Kallas K, Ellezam B, Bakshi R, Prat A, Antel JP, Weiner HL, Quintana FJ. Regulation of astrocyte activation by glycolipids drives chronic CNS inflammation. Nat Med. 2014 Oct;20(10):1147-56. doi: 10.1038/nm.3681.
  • Cui QL, Fang J, Kennedy TE, Almazan G, Antel JP. Role of p38MAPK in S1P receptor-mediated differentiation of human oligodendrocyte progenitors. Glia. 2014 Aug;62(8):1361-75. doi: 10.1002/glia.22688.
  • Leong SY, Rao VT, Bin JM, Gris P, Sangaralingam M, Kennedy TE, Antel JP. Heterogeneity of oligodendrocyte progenitor cells in adult human brain. Ann Clin Transl Neurol. 2014 Apr;1(4):272-83. doi: 10.1002/acn3.55.
  • Miyazaki Y, Li R, Rezk A, Misirliyan H, Moore C, Farooqi N, Solis M, Goiry LG, de Faria Junior O, Dang VD, Colman D, Dhaunchak AS, Antel J, Gommerman J, Prat A, Fillatreau S, Bar-Or A; CIHR/MSSC New Emerging Team Grant in Clinical Autoimmunity; MSSRF Canadian B cells in MS Team. A novel microRNA-132-surtuin-1 axis underlies aberrant B-cell cytokine regulation in patients with relapsing-remitting multiple sclerosis. PLoS One. 2014 Aug 19;9(8):e105421. doi: 10.1371/journal.pone.0105421. eCollection 2014.
  • Butovsky O, Jedrychowski MP, Moore CS, Cialic R, Lanser AJ, Gabriely G, Koeglsperger T, Dake B, Wu PM, Doykan CE, Fanek Z, Liu L, Chen Z, Rothstein JD, Ransohoff RM, Gygi SP, Antel JP, Weiner HL. Identification of a unique TGF-β-dependent molecular and functional signature in microglia. Nat Neurosci. 2014 Jan;17(1):131-43. doi: 10.1038/nn.3599.