Arbour, Nathalie PhD

Research Assistant Professor

Department of medicine, Université of Montréal,
Centre de recherche du CHUM-Hôpital Notre-Dame
Pavillon JA De Sève (Y3609),
1560 Sherbrooke Est Montréal, Qc, Canada, H2L 4M1
(514) 890-8000 (25112)
(514) 412-7602

Research Profile

Human and animal neuroimmunology (mouse models), auto-immunity, multiple sclerosis, T and B lymphocytes, virology, central nervous system, cytokines, in vitro immunological studies, tissue cultures, flow cytometry, cell and molecular biology.

Expertise

Neuroimmunology: Identification of key players involved in the deleterious interaction between the immune system and the central nervous system and thus implicated in the pathogenesis of demyelinating, neurodegenerative and virus-induced diseases. Elucidation of the mechanisms exploited by T lymphocytes (CD8 and CD4) to attack cells of the central nervous system and thus contributing to the pathogenesis of autoimmune diseases such as multiple sclerosis. Characterization of molecules (ligands, cytokines, intracellular proteins) expressed by the central nervous system to locally modulate immune responses.

Recent Publications

Arbour

  • Pickles S, Arbour N, Vande Velde C. Immunodetection of outer membrane proteins by flow cytometry of isolated mitochondria. J Vis Exp. 2014 Sep 18;(91):51887. doi: 10.3791/51887. PubMed PMID: 25285411.
  • Giacomini PS, Rozenberg A, Metz I, Araujo D, Arbour N, Bar-Or A; Maraviroc in Multiple Sclerosis–Associated PML–IRIS (MIMSAPI) Group. Maraviroc and JC virus-associated immune reconstitution inflammatory syndrome. N Engl J Med. 2014 Jan 30;370(5):486-8. doi: 10.1056/NEJMc1304828. PubMed PMID: 24476450.
  • Larochelle C, Lécuyer MA, Alvarez JI, Charabati M, Saint-Laurent O, Ghannam S, Kebir H, Flanagan K, Yednock T, Duquette P, Arbour N, Prat A. Melanoma cell adhesion molecule-positive CD8 T lymphocytes mediate central nervous system inflammation. Ann Neurol. 2015 Jul;78(1):39-53. doi: 10.1002/ana.24415.
  • Podjaski C, Alvarez JI, Bourbonniere L, Larouche S, Terouz S, Bin JM, Lécuyer MA, Saint-Laurent O, Larochelle C, Darlington PJ, Arbour N, Antel JP, Kennedy TE, Prat A. Netrin 1 regulates blood-brain barrier function and neuroinflammation. Brain. 2015 Jun;138(Pt 6):1598-612. doi: 10.1093/brain/awv092.
  • Legroux L, Pittet CL, Beauseigle D, Deblois G, Prat A, Arbour N. An optimized method to process mouse CNS to simultaneously analyze neural cells and leukocytes by flow cytometry. J Neurosci Methods. 2015 May 30;247:23-31. doi: 10.1016/j.jneumeth.2015.03.021.