Fournier, Sylvie PhD

Associate Professor

McGill University, Department of Microbiology and Immunology
3775 University Street, room 616, Montreal, QC H3A 2B4
(514) 398-7273
(514) 398-7052

Research Profile

Our research program focuses on assessing in vivo the consequences of dysregulated expression of tne costimulatory ligand B7.2 (CD86) on T lymphocyte responses and development. We have generated transgenic mouse lines in which various physiologically relevant cell types constitutively express this molecule. We showed that transgenic mice constitutively expressing B7.2 on microglia, a nervous tissue resident antigen presenting cells, spontaneously develop a CD8+ T-cell mediated demyelinating disease. A large part of our current research activities is focused on defining the pathogenic mechanisms involved in this novel animal model of CD8+ T cell-mediated demyelinating disease and the antigenic specificity of the CNS CD8+ T cells that are activated by B7.2-expressing microglial cells.

Expertise

Immunology, Costimulation, B7/CD28/CTLA-4, T lymphocytes, Autoimmunity, Neuroimmunology, Transgenic and knock-out/in mouse models, Flow cytometry, Cell and molecular biology.

Recent Publications

  • Van Den Ham KM, Shio MT, Rainone A, Fournier S, Krawczyk CM, Olivier M. Iron prevents the development of experimental cerebral malaria by attenuating CXCR3-mediated T cell chemotaxis. PLoS One. 2015 Mar 13;10(3):e0118451. doi: 10.1371/journal.pone.0118451. eCollection 2015.
  • Contreras I, Estrada JA, Guak H, Martel C, Borjian A, Ralph B, Shio MT, Fournier S, Krawczyk CM, Olivier M. Impact of Leishmania mexicana infection on dendritic cell signaling and functions. PLoS Negl Trop Dis. 2014 Sep 25;8(9):e3202. doi: 10.1371/journal.pntd.0003202. eCollection 2014 Sep.
  • Yang M, Rainone A, Shi XQ, Fournier S, Zhang J. A new animal model of spontaneous autoimmune peripheral polyneuropathy: implications for Guillain-BarrĂ© syndrome. Acta Neuropathol Commun. 2014 Jan 8;2:5. doi: 10.1186/2051-5960-2-5.