Nalbantoglu, Josephine PhD

Associate Professor

McGill University, Montreal Neurological Institute
3801 University Street, Montreal, QC H3A 2B4
514-398-5920
514-398-7371

Research Profile

There are three broad areas of research in the lab – gene therapy of brain tumours, gene therapy of muscle diseases and functional studies on CAR (coxsackie and adenovirus receptor). We use adenovirus and adeno-associated virus vectors for suicide gene therapy and anti-angiogenic therapy in xenograft models of brain tumours. We are optimizing vascular delivery of viral vectors to disseminated tumours as well as developing gene transfer methods to target cancer stem cells. The study of the physiological function of CAR is a major focus of the laboratory. We have shown CAR to be a suppressor of tumour growth and invasion for gliomas. We are identifying the proteins and pathways which mediate this effect of CAR. As the highest expression of CAR is in the developing nervous system, we are using a variety of approaches to study the role of CAR neuronal function (primary cultures, conditional knockouts, behavioral analysis).

Expertise

Adenovirus-mediated gene therapy of experimental gliomas and medullablastomas using tumour suppressor and 'suicide' genes

Recent Publications

  • Chen H, Nalbantoglu J. Ring cell migration assay identifies distinct effects of extracellular matrix proteins on cancer cell migration. BMC Res Notes. 2014 Mar 27;7:183. doi: 10.1186/1756-0500-7-183.