Piccirillo, Ciriaco PhD

Assistant Professor and Canada Research Chair

Department of Microbiology and Immunology, McGill University and Center for the Study of Host Resistance, MUHC
3775 University Street, Room 510, Montreal, QC H3A 2B4
(514) 398-2872
(514) 398-7052

Research Profile

The research program focuses on the regulation of immune responses mediated by CD4+Foxp3+ Treg, a unique population of cells with potent immunosuppressive and tolerogenic functions in mice and humans. Our laboratory aims to characterize the relative contribution of CD4+ Treg cells as a determining factor in establishing resistance or susceptibility to autoimmune and infectious diseases, as well as controlling immunity to tumors. Our group makes use of cutting-edge experimental strategies to characterize the functional dynamics of CD4+Foxp3+ Treg cell activity in human autoimmune diseases (type 1 diabetes, MS, IBD) as well as in animal models of autoimmunity (type 1 diabetes, EAE), tumours (breast cancer), infections (malaria), and mucosal immunity (IBD). Our research program also focuses on the development of novel immunotherapeutic strategies to manipulate CD4+Foxp3+ Treg cell function and ultimately modulate autoimmune and chronic inflammatory diseases. Our research program makes use of standard and state-of-the-art molecular, cellular and imaging approaches in a variety of gene-modified mouse models (knock-out, transgenic and knock-in) and in human subjects to monitor and characterize the functional dynamics of nTreg cells in health and disease.

Expertise

Cellular and molecular immuno-biology, in vitro immunological studies, human and mouse models of disease, T cells, dendritic cells, cytokines, multi-parametric flow cytometry.

Recent Publications

  • Bin Dhuban K, d'Hennezel E, Nashi E, Bar-Or A, Rieder S, Shevach EM, Nagata S, Piccirillo CA. Coexpression of TIGIT and FCRL3 identifies Helios+ human memory regulatory T cells. J Immunol. 2015 Apr 15;194(8):3687-96. doi: 10.4049/jimmunol.1401803.
  • Blagih J, Coulombe F, Vincent EE, Dupuy F, Galicia-Vázquez G, Yurchenko E, Raissi TC, van der Windt GJ, Viollet B, Pearce EL, Pelletier J, Piccirillo CA, Krawczyk CM, Divangahi M, Jones RG. The energy sensor AMPK regulates T cell metabolic adaptation and effector responses in vivo. Immunity. 2015 Jan 20;42(1):41-54. doi: 10.1016/j.immuni.2014.12.030.
  • Kornete M, Mason ES, Girouard J, Lafferty EI, Qureshi S, Piccirillo CA. Th1-Like ICOS+ Foxp3+ Treg Cells Preferentially Express CXCR3 and Home to β-Islets during Pre-Diabetes in BDC2.5 NOD Mice. PLoS One. 2015 May 6;10(5):e0126311. doi: 10.1371/journal.pone.0126311. eCollection 2015.
  • Pagliari D, Piccirillo CA, Larbi A, Cianci R. The Interactions between Innate Immunity and Microbiota in Gastrointestinal Diseases. J Immunol Res. 2015;2015:898297. doi: 10.1155/2015/898297. Epub 2015 May 20.
  • Massoud AH, Kaufman GN, Piccirillo CA, Mazer BD. Reply: To PMID 24210883. J Allergy Clin Immunol. 2014 Dec;134(6):1469-70. doi: 10.1016/j.jaci.2014.08.050.
  • Lafferty EI, Flaczyk A, Angers I, Homer R, d'Hennezel E, Malo D, Piccirillo CA, Vidal SM, Qureshi ST. An ENU-induced splicing mutation reveals a role for Unc93b1 in early immune cell activation following influenza A H1N1 infection. Genes Immun. 2014 Jul-Aug;15(5):320-32. doi: 10.1038/gene.2014.22.
  • Piccirillo CA, Bjur E, Topisirovic I, Sonenberg N, Larsson O. Translational control of immune responses: from transcripts to translatomes. Nat Immunol. 2014 Jun;15(6):503-11. doi: 10.1038/ni.2891. Review.
  • Bin Dhuban K, Kornete M, S Mason E, Piccirillo CA. Functional dynamics of Foxp3⁺ regulatory T cells in mice and humans.Immunol Rev. 2014 May;259(1):140-58. doi: 10.1111/imr.12168. Review.
  • Massoud AH, Yona M, Xue D, Chouiali F, Alturaihi H, Ablona A, Mourad W, Piccirillo CA, Mazer BD. Dendritic cell immunoreceptor: a novel receptor for intravenous immunoglobulin mediates induction of regulatory T cells. J Allergy Clin Immunol. 2014 Mar;133(3):853-63.e5. doi: 10.1016/j.jaci.2013.09.029.
  • Zouk H, D'Hennezel E, Du X, Ounissi-Benkalha H, Piccirillo CA, Polychronakos C. Functional evaluation of the role of C-type lectin domain family 16A at the chromosome 16p13 locus. Clin Exp Immunol. 2014 Mar;175(3):485-97. doi: 10.1111/cei.12240.